John Robert Isner is born to Robert and Karen. His older brother Jordan is a trainer in tennis. For four years John received the All-American honours for each season at the University of Georgia from 2004 to 2007. He was the number one player in their school in the singles and doubles categories. He led his team to compete in the championship title at the NCAA. Reaching the finals in the NCAA, he won the doubles title but lost the finals game in the singles division to Somdev Dev Varman of Virginia during the third set game.
John was born in Greensboro, North Carolina, USA on April 26, 1985. He now resides in Tampa, Florida USA. He began holding the racquet when he was nine years old. Playing best in his right hand, John became a professional tennis player in 2007. He likes playing in hard courts and considers forehand his best shot. He is coached by Kelly Jones, a former ATP pro.
He also likes to play poker, golf, and basketball. He looked up at Karl Malone, a former NBA star, as his idol in the sports. With his 6’3” towering height, he claimed to have become a professional basketball player if he was not into tennis today.
In 2005, John reached the quarterfinals at USTA and won the doubles title together with Wurtzman. In 2006, he advanced to the singles and doubles finals. That same year he was the runner-up at the Lexington Challenger with Purcell. In 2007, the following year, Isner made a breakthrough in the ATP circuit and finished in the Top 125. He made his debut at Newport and has a 5 ATP level play record. He also has a 12-5 in the Challenger.