Akgul Amanmuradova was born and raised and Tashkent. She started playing tennis at age ten with her grandmother taking her to the tennis club to play. She was a member of the East Asia Grand Slam Development funded by the ITF and the Tashkent State Fund. At age 18, she got in the national tennis team and decided to pursue the sport as a professional career.
The 24-year old played her first career tournament on the ITF Circuit in 2000. She played at Tashkent in 2001 but fell after the first round. She tried again the next year but was unable to make it past the first round. However, she earned her first ITF doubles title with K. Bondarenko.
In 2003, she earned four ITF singles title, one in Mumbai 1, another in Incheon and a final win at Mumbai 3. She also won the doubles title in Mubai 1 with Khoo and in Chennai, India with Isroilova. In 2004, Akgul won three singles title at Coimbra, Pune and Bangkok. The same year, she also won the doubles title in Alkmaar, Coimbra and Pune.
She fell on the WTA Tour qualifying rounds in Hyberabad. The next year, she came back with a runner up finish at Tashkent losing to fifth seed Krajicek. She participated in two main draw Tour events, getting to the second round at the Pattaya City Open and Hyberabad. 2005 also earned her an ITF doubles title in Phuket paired with Tongsalee.
In 2006, she played her first Grand Slam event at the Australian Open reaching the second round. By 2007, she was already in the Top 100 reaching the 99th spot with a semifinal finish at Cincinnati as well as quarterfinals at Tashkent. Akgul also won an ITF singles title in Mubai as well as the doubles title in the same tournament. Her best finish this year was the semifinals at the Pattaya City Open.