Mirko Guadalupi
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| Position | Midfielder |
| Height / weight | 1.84 m / - |
| Born | 9 Jan 1987 (39 years) |
| Nationality |  Italy |
Mirko Guadalupi is a young Italian football player who is on the books of the Italian Serie A club AC Siena. He plays as a midfielder and is currently on loan to Italian Serie B side Ancona.
Mirko Guadalupi commenced his professional club football career at Perugia in 2005 and played for them until 2007, scoring 5 goals in 35 league matches. He was then signed by Siena in 2007 and in the summer of 2008 was sent on loan to Italian Serie B side Ancona for the 2008-2009 season.