There was a sizeable gulf in glass between this pair when they met in the first leg and Real Madrid should qualify comfortably on Tuesday night.
With a place in the Champions League semi-finals up for grabs I expect Jose Mourinho to take no chances and the 1.70 about his team prevailing on the night appeals.
Real Madrid travel with a 3-0 lead to Turkey but, while clearly they do not need to win the match to advance, the nine-time European champions only know how to play one way.
I expected more from Galatasaray in the first leg but goals from Cristiano Ronaldo and Karim Benzema before half-time all but settled the tie.
When Gonzalo Higuain added a third in the 73rd minute it left the Turkish Super Lig leaders with a mountain to climb and Real Madrid are finding their stride at just the right time of the season.
While there is no chance of catching Barcelona in La Liga it is now 12 matches without defeat in all competitions, winning on ten occasions.
A 5-1 thrashing of Levante on Saturday, having fallen behind, confirmed their wellbeing and if Mourinho’s men can triumph at Old Trafford, albeit against ten men, then Istanbul should hold no fears.
The hosts will be missing top scorer Burak Yilmaz at the Turk Telecom Arena through suspension and that is a blow.
Didier Drogba will lead the line but the Ivorian looked off the pace in Spain and whether he has what it takes to carry the fight to the visitors on his own is debatable.
All looks in place for yet another Madrid master class and an early goal would certainly end the tie.
I can’t resist backing them at the prices on offer. Madrid were just 1.16 shots in the Bernabeu last week.
2pts Back Real Madrid (vs. Galatasaray) @ 1.70 (various)