Born in Uruguay, Hernan Rodrigo Lopez began his professional football career at River Plate de Montevideo, in 1996. For two years, he played with the team without making any significant impact and then moved to AO Kavalas in 1998. In the same year, he went to Torino FC in the Serie B but came back to Uruguay to play for River Plate again. In 2000, he moved to Colo-Colo and then to Danubio FC. These one-year stints were followed by another year run at Racing Club de Montevideo before he went to Olimpia in 2002.
At Olimpia, the team won the Copa Libertadores title in 2002 and as a result, Lopez won a winners’ medal although he wasn’t of any significant contribution to the squad. In 2003, his second season with the club, they won the Recopa Sudamericana before he left Olimpia for Pachua in 2004 and then Libertad in 2005.
With Libertad, Lopez won his first ever medal in the Paraguayan first division. In the same year, he scored 27 goals for Libertad, winning the award for the top-scorer in the league as well. After another season at Libertad, Lopez came to Club America in 2007 and then to Velez Sarsfield in 2008.