Norwegian champions Molde FK snapped the winning run of home teams in the one-off UEFA Champions League qualifiers on Wednesday, while Dinamo Zagreb, Red Star Belgrade and Young Boys were among the early casualties.
Molde FK defeated Azerbaijani champions Qarabag 6-5 on penalties after a 0-0 draw, although the match was played in neutral Larnaca due to travel restrictions.
The Norwegian champions will play Hungarian champions Ferencvaros in the play-off round across two legs for a spot in the Champions League group stage proper.
Ferencvaros got past Croatian champions Dinamo Zagreb 2-1 thanks to Myrto Uzuni’s 65th minute winner.
Red Star Belgrade were knocked out of the race for a spot in the group stage after a 4-2 penalty shootout loss to Omonia Nicosia in Cyprus.
Omonia’s win sets up a clash between the Cypriot and Greek champions, with Olympiacos waiting in the wings in the play-off round.
Midtjylland will play Czech champions Slavia Prague in the play-off round, while Maccabi Tel Aviv edged Belarussian champions Dinamo Brest 1-0 to qualify for the next phase.
Maccabi will play Austrian powerhouse Red Bull Salzburg in the play-off round, with matches to be played on September 22-23 and September 29-30.
Europa League qualifying will continue on Thursday, with Rangers, Tottenham, Galatasaray and AC Milan among the big clubs in action.