Australia have swung the selection axe on out-of-form batsman Usman Khawaja to make way for the returning Steven Smith for the Fourth Ashes Test at Old Trafford starting on Wednesday.
The tourists announced their 12-man squad for the Fourth Ashes Test on Monday, with Smith the big inclusion following concussion.
Khawaja, who captained Australia in a three-day tour-match against Derbyshire this week, has managed 122 runs from six knocks at an average of 20.33.
Wade has more runs across six innings, with 151, although 110 came in one knock, his century in the First Ashes Test victory.
Harris has only played one Test this series, managing only scores of 8 and 19, having replaced Cameron Bancroft.
Mitchell Starc could force himself into the Australian XI after a seven-wicket haul against Derbyshire.
Meanwhile, England have made a change to their battling line-up with Joe Denly to be elevated to open, with Jason Roy dropping down the order.