Handscomb has been brought into the Australian 15-member squad following an arm injury to Shaun Marsh.
Usman Khawaja has also gone down injured with a hamstring problem which has ruled him out of the tournament, opening up a spot in the XI.
There had been speculation Matthew Wade or Mitch Marsh could come into the side, but Langer confirmed they’d opted for the Victorian batsman.
“I’ll tell you the truth. Peter Handscomb will definitely play, 100 per cent,” Langer said.
“He deserves it, he was really stiff not to be on this tour. He was so unlucky not to be in the initial squad after what he’d done to help us get to that point.
“He’s in good form, he played well for Australia A, he gives us nice balance through that middle order, he’s got great temperament, he plays the spin well and he’s on top of his game. So he’ll definitely play.”
Marcus Stoinis has been under an injury cloud prompting talk about Marsh but Langer indicated he may be fit to take his place against the English.
“He looks good,” Langer said.
“It was a very good net session actually, there was a bit of heat again, it was very competitive and that always brings the best out in Stoin.
“He did a good job today and he’s fit to go.”
There has also been speculation Wade could replace struggling all-rounder Glenn Maxwell.
Maxwell has managed 155 runs from nine innings with an average of 22.14 and no half-centuries.
“We’ll pick our 11 and you’ll see it at the toss,” Langer said.