- Sport: hockey
- Team: Columbus Blue Jackets
- Position: centre
- Nationality: Canada

- Birth date: 1981-06-11 (27 years)
- Place of birth: Sudbury, ON, Canada
Derek Mackenzie is a Canadian center on the Columbus Blue Jackets.
Mackenzie was drafted in 1999 by the Atlanta Thrashers and played there from 2001 until 2007. He signed with Columbus in 2007. In five NHL seasons, Mackenzie has played only 45 games and has recorded 4 points.

Mackenzie was drafted in 1999 by the Atlanta Thrashers and played there from 2001 until 2007. He signed with Columbus in 2007. In five NHL seasons, Mackenzie has played only 45 games and has recorded 4 points.

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