Candice Dupree was born August 16, 1984 in Oklahoma City, Oklahoma, but grew up in Tampa, Florida. She has two siblings - a twin sister, and a younger sister.

University
Candice attemnded Temple University, graduating in 2006. She played basketball for the Owls. In her career, she was named Atlantic 10 and Philadelphia Big Five Player of the Year in 2005, as well as 2005 Associated Press All-America honorable mention, and 2005 Atlantic 10 Defensive Player of the Year. She was also a member of the 2005 Atlantic 10 first team and two-time Big Five first seam selection in 2004 and 2005.

WNBA
Candice was the 6th overall pick in the 2006 WNBA Draft by the Chicago Sky. As a rookie, she was named to the eastern conference WNBA all star team.